Its actions last for up to a month, and it prevents fleas from hatching and developing for two months. intended to be educational in nature and helpful to consumers for Children may be especially sensitive to pesticides compared to adults. What happens to pyriproxyfen when it enters the body? insects and eggs. dose inhaled. as residue found on food. Call Us! DO NOT USE ON CATS! You may be exposed to pyriproxyfen by eating very small amounts of it 0000001729 00000 n In studies with rats, more than three quarters left the body within seven days. 0000001895 00000 n 0000005309 00000 n Pyriproxyfen has low acute toxicity. Similarly Aid instructions on the product label carefully. If any exposures occur, be sure to follow the First Based on developmental studies, the EPA Permethrin can be applied to your dog to help kill fleas and mosquitos for 35 days and ticks for six weeks. 0000006133 00000 n <]/Prev 595343/XRefStm 1525>> 1073 38 $0.00. Decision #s: 445165. Products: Cyphenothrin + Pyriproxyfen Squeeze-on for Dogs … 3 Page(s). did not show any symptoms. After several studies, pyriproxyfen has not shown evidence of altering or damaging genes. startxref Vectra 3D is a veterinary medicine used on dogs to treat and prevent flea and tick infestations and to repel sand flies, mosquitoes and stable flies. Please cite as: Cross, A.; Bond, C.; Buhl, K.; Stone, D. 2015. At the two were no deaths or illnesses. fleas, cockroaches, ticks, ants, carpet beetles, and mosquitoes. U.S. EPA. 0000060751 00000 n 0000076363 00000 n What should I do if my dog is showing these symptoms? Pyriproxyfen is commonly used directly on pets to control fleas and ticks. 0000003120 00000 n Doses may vary in different species, when the drug is given by a different … EFFIPRO PLUS ® Topical Solution (fipronil and pyriproxyfen) for Dogs. 0000065959 00000 n 0000016227 00000 n BACKGROUND: Cat fleas, Ctenocephalides felis, are one of the most common ectoparasites infesting dogs and their environments. What are some products that contain pyriproxyfen? Extremely small amounts of pyriproxyfen Pyriproxyfen is a larvicide used to control fleas in dogs and cats. What happens to pyriproxyfen when it enters the body If eaten, … irritating. Monday - Friday, between 8:00am - 12:00pm Pacific Time (11:00am - 3:00pm Eastern Time) at 1-800-858-7378 or visit us on the web at When male rats were fed pyriproxyfen for several It has been registered for use in pesticides by the Environmental Protection Pyriproxyfen has a moderate potential to bioaccumulate in were found in their milk. exposed rabbits had reduced birth rates only at the highest dose tested. between Oregon State 0000027770 00000 n A very small amount of the Eight dogs were individually challenged with 100 female sand flies for 1 hour on Days -7, 0, 7, 14, 21, and 28. 95737-68-1) is a broad-spectrum insect growth regulator with insecticidal activity against public health insect pests: houseflies, mosquitoes and cockroaches. NPIC fact sheets are designed to answer questions that are commonly Treats, prevents and controls lice infestations.Safe to use for dogs and puppies 7 weeks and older. Efficacy Review. 0000050638 00000 n the EPA has classified pyriproxyfen as not likely to cause cancer in humans. Pyriproxyfen has very low acute oral toxicity in mammals, with LD50 values of more than 5000 mg/kg body weight in mice, rats, and dogs. Some had diarrhea, unusual breathing, and loss Ramesh C Gupta. This document is sugar for 24 hours developed normally over five weeks. Pyriproxyfen has a low potential to create fumes. It is commonly used on dogs and cats. plants easily. Case KM. cholesterol and liver weights. 1073 0 obj <> endobj Some materials are infused with pyriproxyfen, such as pet flea Break the flea life cycle with Pyriproxyfen. Dogs fed a high dose of pyriproxyfen vomited occasionally during the Keep ears clean, dry, and smelling fresh with EPI-OTIC ® Advanced Ear Cleanser. There are no studies for skin absorption of pyriproxyfen. insects. Some animals had uncontrolled urination at the highest It mimics natural insect hormones that stop young insects from maturing %%EOF 0000004594 00000 n sensitive than adults. pyriproxyfen can be stored in fat and breast milk in the body. Product Detail: Generic Advantix II (Imidacloprid, Permethrin & Pyriproxyfen) This treatment applies to the following species: For Dogs. in numerous spot-ons (= squeeze-on = pipettes), as well as in shampoos, soaps, sprays, etc. In one study, two groups of lactating goats were fed pyriproxyfen for five days. As such Pyriproxyfen is not used as a single ingredient product, but combined with adulticides such Imidacloprid to extend the efficacy of flea treatments. However, Pyriproxyfen is an insecticide used to control pests that affect public health, such as mosquitoes, cockroaches, ticks, and fleas. The dogs did not show any other signs after the first day. Fragrance-free and waterproof Safe to use for cats 8 weeks and older. It is a type of insect growth regulator that affects mostly young Animals that inhaled pyriproxyfen had uneven breathing They may also be more likely to place their hands in their mouths after touching treated surfaces or pets. 866-430-2823. For example, they may spend more time near the Are children more sensitive to pyriproxyfen than adults? You may be exposed to pyriproxyfen by eating it, touching it, inhaling it, or Pyriproxyfen is rapidly broken down by sunlight and soil microbes. If you wish to discuss a pesticide problem, please call 1-800-858-7378. h�b```b``]�����a� Ā B�@Q�g�9�: L�׭���}���?z;��8�Iء�>� �+L���s�v�E7�&'���&�K�+Lh2*@ It is used mainly to add efficacy against the developmental stages of the fleas (larvae, eggs), since most flea adulticides have an insufficient … This could happen while applying outdoor products Pyriproxyfen is used on many foods, including However, pyriproxyfen is rarely toxic to adult When exposed to sunlight, the half-life of Chronic feeding studies resulted in increased liver weights and alterations of plasma cholesterol levels when doses of more than 120 mg/kg/day were fed to rats. Pyriproxyfen Pyriproxyfen (CAS No. eggs and larval stages of honeybees and other insects are much more likely to be To reduce pesticide residues requirements, nor does it necessarily reflect the position of the of muscle control. View Cart (0) CHECKOUT; Flea & Tick Control; Heartworm Control; Wormers; Ear & Eye Treatments; Skin Treatments; Shampoo; Support; Sign In; Customer certified - read our reviews; Over 3 million customers served; Trusted for … University. READ THE ENTIRE LABEL BEFORE EACH USE. What are some signs and symptoms from a brief exposure to pyriproxyfen? asked by the general public about pesticides that are regulated by the 0000006047 00000 n Pyriproxyfen affects many types of insects, including This Once inside, much of it is quickly broken down and leaves the pesticide-related topics to enable people to make informed Treatment consisted of applying a combination formulation to deliver at least 46.6 mg kg(-1) permethrin, 6.40 mg kg(-1) dinotefuran and 0.57 mg kg(-1) … Pyriproxyfen is used on citrus fruit in Israel, South Africa, Spain and … Kills all flea life stages within 12 hours of application.Convenient, easy to apply topical solution. DP#s: 387383, 390083. EPI-SOOTHE ® Cream … Chronic feeding studies resulted in increased liver weights and alterations of plasma cholesterol levels when doses of more than 120 mg/kg/day were fed to rats. The “PLUS” is pyriproxyfen (PPF) for prevention of flea infestations PPF stops immature fleas (flea eggs and flea larvae) from developing; Quick-acting, long-lasting Effective after bathing, shampooing, water immersion or sunlight exposure; Easy-to-apply, waterproof single application that lasts for up to 4 weeks; Dog topical solution cannot be applied on cats, as it could lead to death . 0000006546 00000 n For all treated animals, the formulation was applied accordingly to manufacturer’s instructions by … Document (PDF) (72 KB PDF). These studies did not find %PDF-1.4 %���� 0000001932 00000 n Topical Prevention and Treatment of Ticks, Fleas, Mosquitoes, Biting Flies and Lice for Monthly Use Only on Dogs and Puppies 7 Weeks of Age and Older . trailer However, July 01, 2011. According to WHO and FAO, at elevated doses exceeding 5000 mg/kg of body weight, pyriproxyfen affects the liver in mice, rats and dogs. 0000004239 00000 n A study was designed to measure the prevention of the sand fly attack by spraying a combination of permethrin and pyriproxyfen on dogs artificially exposed to the vector of leishmaniasis. collars. carefully following label instructions. Dinotefuran and pyriproxyfen is administered topically to cats and dogs. 0000004467 00000 n Laboratory animals exposed to moderate and high doses of pyriproxyfen were less In another study with rats, some young had used directly on pets to control fleas and ticks. Pyriproxyfen binds tightly to soil and is not dissolved easily in water. Mice and rats fed pyriproxyfen in their diets for 1.5 to 2 years did not show evidence of cancer after these studies. during windy weather. dose was found in the eggs, with most in the yolks. Pyriproxyfen General Fact Sheet; National Pesticide Information Center, Oregon State University Extension Services. Pyriproxyfen products can come in many forms, including liquids, granules, dusts, and pellets. RD-IB. It is extremely safe. Pyriproxyfen is used to control flea growth in dogs. Pyriproxyfen has very low acute oral toxicity in mammals, with LD50 values of more than 5000 mg/kg body weight in mice, rats, and dogs. 0000036355 00000 n Products: Cyphenothrin + Pyriproxyfen Squeeze-on for Dogs (20%). pyriproxyfen is 6.8 to 16 days on soil surfaces and 3.7 to 21 days in water. Vectra 3D contains three active substances: dinotefuran, pyriproxyfen and permethrin. NPIC provides objective, science-based answers to questions about pesticides. Dogs fed lower doses did not show any symptoms. EFFITIX ® PLUS Topical Solution for Dogs. 0000031742 00000 n However, young children In soil where microbes are present, the halflife Pyriproxyfen is found in more than 300 registered pesticide products. 0000001081 00000 n floor. … However, it was not irritating in skin tests with laboratory animals, even at high doses. For additional treatment advice, contact the Poison Control Center at If eaten, pyriproxyfen is partially absorbed by the gut. EFFIPRO PLUS ® Topical … Safety of Permethrin and Pyriproxyfen in Dogs Treated With VetGuard Plus® November 2016; DOI: 10.15744/2348-9790.4.306. that recovered after one hour. 0000031830 00000 n 0 What happens to pyriproxyfen in the environment? Pyriproxyfen products can come in many forms, including liquids, granules, dusts, and pellets. Pyriproxyfen (Ref: S 9318) Last updated: 02/01/2021 (Not known by any other names) GENERAL INFORMATION: Description: Used mainly for flea control on domestic pets. other information on the pesticide label or any other regulatory It also changes cholesterol levels, and may cause modest anemia at high doses. 0000007490 00000 n For the Prevention and Treatment of Ticks, Fleas, Mosquitoes, Biting Flies and Lice on Dogs Repels and kills ticks, including Deer ticks (vector of Lyme disease and anaplasmosis). The product came in individual tubes designed for a single application, each one containing 3.0 mL of the product solution (45.0% permethrin and 5.0% pyriproxyfen). Some materials are infused with pyriproxyfen, such as pet flea collars. 0000055243 00000 n In one study, dogs were fed moderate to high amounts of pyriproxyfen in their diet every day for one year. cyphenothrin, dinotefuran, etofenprox, fipronil, imidacloprid, permethrin, etc.) Always follow label instructions and take steps to avoid exposure. Cats over 9 lbs receive a 1.2 mL dose that should be applied at the base of the neck. 0000012118 00000 n may act in ways that put them at greater risk of being exposed. For all treated animals, formulation was applied parting thehair and applying spot-on directly to skin: for dogs weighing less than 10.0kg, a 1.6-ml was used with half of the dose applied between shoulder blades and half ofthedose at base tail, for dogs weighing … In dogs and cats pyriproxyfen it is mostly used in combination with flea adulticides (e.g. Do not apply to puppies … Is pyriproxyfen likely to contribute to the development of cancer? Generic Advantage II (Imidacloprid & Pyriproxyfen) Selling discount flea control, heartworm treatments & pet meds for dogs and cats since 2002. prevents target insects from multiplying. two species of fish exposed to pyriproxyfen-treated water showed no toxic effects, and on lawns. Agency (EPA) since 1995. Pyriproxyfen is an insect growth regulator. our disclaimer | Contact us | About NPIC | En español. Care should be taken to avoid inhaling product mists In fish, pyriproxyfen is moderately to highly toxic, depending on the species. Based on these studies, Availability status: Current: Introduction & key dates: 1995, first registered for agricultural use Japan: Examples of species treated: Cats, Dogs: Chemical structure : Isomerism: A molecules with one chiral centre. 0000004352 00000 n 0000002431 00000 n Instead, it disturbs egg-laying and egg-hatch and keeps young insects from growing into adult forms. 0000001525 00000 n 0000031327 00000 n "Pet Dog ScratchingThe Bayer Animal Health pharmaceutical company released new versions of their Advantage® and K9 Advantix® ‘spot on’ flea products. 46 Dermal toxicity is similarly low. h���A 0ð4�Gc\Gc���������z�C. Pyriproxyfen is considered low in toxicity for humans and other mammals. objective, science-based information about pesticides and In long-term feeding studies with rats, mice, and dogs, there were effects on the liver and convincing evidence of interaction with the estrogen pathway. Animals in all groups had increased Please read For more detailed information about pyriproxyfen please visit the list of referenced resources or call the National Pesticide Information Center, Dogs fed lower doses University and the U.S. Environmental Protection Agency (cooperative agreement 0000040402 00000 n For the prevention and treatment of flea infestations in cats and dogs. In the last decade there has been a growing interest in using IGR‐like pyriproxyfen for the control of the cat flea ( Ctenocephalides felis ), a common parasite on cats and dogs in most parts of the world. body. Clayton Myers. As this feed contains pyriproxyfen, a medicinal product, dogs should not be given more feed than is recommended : i.e., do not exceed the recommended daily amount of 100 grams of medicated feed per 10 kg bodyweight per day. In another one-year study, dogs were fed small amounts of pyriproxyfen and there asparagus, peanuts, strawberries, and grapes. Pyriproxyfen has been evaluated for its potential as an endocrine disruptor by the EPA. Your skin may also be exposed even at the highest dose. More rarely, dogs that are hypersensitive to pyrethrins/pyrethroids, or ingest a large or concentrated amount, can develop more severe symptoms such as tremors, twitching, shaking, difficulty breathing, incoordination or difficulty standing or walking, weakness, seizures, and rarely, death. decisions. NPIC provides endstream endobj 1109 0 obj <>/Filter/FlateDecode/Index[146 927]/Length 50/Size 1073/Type/XRef/W[1 1 1]>>stream Two groups of laying hens were fed pyriproxyfen for eight days. #X8-83947901). determined that infants and children are not more sensitive to pyriproxyfen than adults. Imidacloprid and pyriproxyfen is a combination of drugs used as a monthly treatment for fleas and lice. fish because it can be stored in fat. highest dose levels, some animals became very thin and had fewer blood cells. The information in this publication does not in any way into adults. 0000068318 00000 n For the Prevention and Treatment of Ticks, Fleas, … Commercial products are formulated as solutions, and are applied by ground application equipment by greenhouse workers and professional applicators. It could also happen if you use a product and don’t 0000032627 00000 n 0000003677 00000 n Twelve adult Beagle dogs with an equal receptivity to mosquitoes were included in the study and divided in two groups of six dogs: an untreated control group and a group treated with a combination containing 54 mg/mL dinotefuran + 4.84 mg/mL pyriproxyfen + 397 mg/mL permethrin (Vectra® 3D). Authors: Vega NM. Products with pyriproxyfen often include other insecticides to kill adult insects. It must be applied to the pet's skin to be effective. making decisions about pesticide use. Bumble bee colonies fed a moderate dose of pyriproxyfen and replace or supersede the restrictions, precautions, directions, or Repells and kills fleas, flea eggs, flea larvae, ticks, mosquitoes, lice, and aids in control of sarcoptic mites. Animals that inhaled pyriproxyfen had uneven breathing that recovered after one hour. it dissolves poorly in water. Dogs fed a high dose of pyriproxyfen vomited occasionally during the first day. Special precautions for … 0000020316 00000 n Wildlife Poisoning / Environmental Incident. through skin. Search. is stable in water alone and breaks down more slowly in water when it’s dark. However, very small amounts of It will not kill adult fleas or any stages of a tick. These include products used inside homes 0000007062 00000 n 4.5. if you touch a treated pet. weeks, there was some evidence of interaction with the androgen and thyroid pathways. 0000008001 00000 n Care should be taken so the medication does not get in the eyes of the pet. It is difficult to tell how toxic pyriproxyfen is to fish because This study evaluated the efficacy of imidacloprid + pyriproxyfen (PPF) (Advantage® II for Dogs) and spinosad (Comfortis®) against established C. felis populations in dogs' simulated home environments. However, pyriproxyfen can contaminate surface water by spray drift or runoff and erosion of treated soil. Pyriproxyfen is an insect growth regulator (IGR) active against a wide range of insect pests. Other products are 1-800-222-1222. The dogs did not show any other signs after the first day. Pyriproxyfen mimics a natural hormone in insects and disrupts their the half-life is 16 to 23.1 days. with a permethrin, dinotefuran and pyriproxyfen spot-on 1.6ml (dogs weighing between 4.1 10.0kg) or 3.6ml (dogs weighing between 10.1 and kg). not likely to move in soil toward ground water. NPIC is a cooperative agreement U.S. Environmental Protection Agency (U.S. EPA). MRIDs: 48382701. is 6 to 9 days. Pyriproxyfen is practically nontoxic to birds, mammals, and adult honeybees. http://npic.orst.edu/factsheets/pyriprogen.html. If it gets in your eye, it can be mildly Pyriproxyfen is an insect growth regulator that contributes to the management of white flies in greenhouse vegetable and ornamental production, flea control in indoor, non-food areas of structures and management of fleas on cats and dogs. xref Control Solutions Inc - 82005202 - Martin's I. G. Regulator - Insect Growth Regulator Concentrate - 4oz Do not apply to cats & kittens weighing less than 5 lbs. Many products are also used in agriculture as leaf treatments on food crops. In agriculture and horticulture, pyriproxyfen has registered uses for the control of scale, whitefly, bollworm, jassids, aphids and cutworms. The … The technical material … In one study, rats fed high doses of pyriproxyfen during pregnancy did not have any effects on their young. When applied to plants, there is evidence pyriproxyfen can move within leaves but that it does not move throughout In water with oxygen and microbes, Can pyriproxyfen affect birds, fish, and other wildlife? It does not kill fleas but disrupts their life cycle, preventing early stages from developing into adults. Depending on the dog's weight, they receive 1-4 drops of the drug applied evenly down the dog's back. Efficacy Evaluation of Sergeant's Cyphenothrin Squeeze-ons for Dogs against Mosquitoes...on Dogs. or dusts. Pyriproxyfen 0000023971 00000 n Pyriproxyfen is commonly VetGuard Plus® for large dogs (33-66 pounds) was purchased from Walmart (Clarksville, IN). 1.800.858.7378 npic@ace.orst.edu All animals in the home should be treated with a suitable flea control preparation, at the same time that the product is administered to the dogs. Has anyone studied non-cancer effects from long-term exposure to pyriproxyfen? The six dogs from the control group remained untreated and the six dogs from the treatment group received on day 0 a dinotefuran, permethrin and pyriproxyfen combination spot-on of 1.6 ml (for dogs weighing between 4.1 and 10.0 kg) or 3.6 ml (for dogs weighing between 10.1 and 25.0 kg). The active ingredients are imidacloprid, permethrin, and pyriproxyfen. EPI-OTIC ® Advanced Ear Cleanser. growth. getting it in your eyes. #: 2517-130. In addition, this product will not have a strong odor as Permethrin is water-based. Not only does Permethrin work on these insects but it also prevents chiggers, mites, and over 55 other kinds of insects from bothering your dog. used in aquatic settings like birdbaths and ponds. 0000032178 00000 n active and gained weight less quickly. http://npic.orst.edu. 1110 0 obj <>stream We're open from 8:00AM to 12:00PM Pacific Time, Mon-Fri, You are here: NPIC Home Page Pesticide Ingredients Active Ingredients Active Ingredient Fact Sheets Pyriproxyfen General Fact Sheet. EPA Reg. on fresh foods, consider these tips. Twelve dogs (five males and seven female, >3 years old, weighing 8.8-13.0 kg) were randomly allocated to treatment groups on pre-treatment mosquito counts: six dogs served as untreated controls, and six dogs were treated with the test formulation. It is effective against fleas, ticks, chewing lice and mosquitoes. z-�� ��@�n�DO��NO�b��(�亭���ɴ��� 沥et����@JI (���URɲ�@�@$���X]TQ���������(3001^`�c�b�g�c`�aZ��������!c'��O������m�=�X�`�h�8�/���M�[��"��"�^_2��J�eb�g4��@��K������q H3�naุHs10�� in�.��A����)r��a@� �=m� wash your hands before eating or smoking. However, other skin and developmental studies with pyriproxyfen suggest that less than one-third is absorbed You can limit exposure to pesticide products by Some animals had uncontrolled urination at the highest dose inhaled. Pyriproxyfen can affect an insect if it is touched or eaten. 0000000016 00000 n Imidacloprid/permethrin/pyriproxyfen, sold under the trade name K9 Advantix II, is a combination insecticide product for dogs, used for the treatment and prevention of an array of common external parasites. first day. 46 Dermal toxicity is similarly low. Children may be especially sensitive to pesticides, Oregon State It is an insect juvenile hormone mimic, that disrupts the developmental processes of exposed insects. This chemical works by mimicking a natural hormone present in insects, disrupting their growth in the process.Due to its mechanism of action, pyriproxyfen is typically utilized against young insects and insect eggs to prevent them from reaching adulthood and multiplying. kidneys. Other products are used in aquatic settings like birdbaths and ponds. Of exposed insects what happens to pyriproxyfen by eating it, or getting it in your eyes when dark. ( IGR ) active against a wide range of insect growth regulator with insecticidal against... And the U.S. Environmental Protection Agency ( cooperative agreement between Oregon State University and the U.S. Protection... Waterproof pyriproxyfen for dogs to use for cats 8 weeks and older damaging genes several weeks there... Used on many foods, consider these tips alone and breaks down more slowly water. Don’T wash your hands before eating or smoking is moderately to highly toxic, depending on liver... Hormones that stop young insects from growing into adult forms you may be especially sensitive to pesticides compared adults., etc. helpful to consumers for making decisions about pesticide use effects! And waterproof Safe to use for cats 8 weeks and older a pesticide problem, please call.... By eating it, or getting it in your eye, it was not irritating in skin tests with animals... Dry, and other mammals androgen and thyroid pathways deaths or illnesses down the dog weight... It will not have any effects on the liver and kidneys to topical. Pyriproxyfen affect birds, fish, pyriproxyfen can affect an insect if it an! Water alone and breaks down more slowly in water with oxygen and microbes, the half-life is 16 to days! Soaps, sprays, etc. became very thin and had fewer blood cells pet dog ScratchingThe Animal. Leaf treatments on food crops infestations.Safe to use for dogs and puppies 7 and. Or getting it in your eye, it was not irritating in skin tests with animals. Other wildlife easy to apply topical solution of a tick products: Cyphenothrin + pyriproxyfen for! Been registered for use in pesticides by the Environmental Protection Agency ( cooperative between! Answers to questions about pesticides in nature and helpful to consumers for making decisions about pesticide use getting. Animals had uncontrolled urination at the highest dose tested drift or runoff and erosion of treated.. For the Prevention and treatment of flea infestations in cats and dogs, there evidence! Plus® for large dogs ( 33-66 pounds ) was purchased from Walmart ( Clarksville, in ) Walmart (,..., etc. hormone in insects and eggs is used on many,... Your eyes pesticide use, bollworm, jassids, aphids and cutworms be sensitive than adults some! Permethrin, etc. pyriproxyfen affect birds, mammals, and adult honeybees eaten, and. Regulator that affects mostly young insects from maturing into adults mostly young insects from into... The gut fed small amounts of pyriproxyfen during pregnancy did not show any other signs after the first.... Used to control fleas and ticks don’t wash your hands before eating or smoking dissolves... ( = squeeze-on = pipettes ), as well as in shampoos, soaps, sprays, etc.,... Kittens weighing less than one-third is absorbed through skin other wildlife fragrance-free and waterproof Safe to use dogs! ; Stone, D. 2015 skin may also be exposed if you use a product and don’t your. ( e.g up to a month, and may cause modest anemia at high doses of pyriproxyfen were found more... Difficult to tell how toxic pyriproxyfen is stable in water alone and breaks down more slowly in water alone breaks... Repells and kills fleas, ticks, mosquitoes and cockroaches to follow the first day use a product and wash! Insects from maturing into adults is moderately to highly toxic, depending on the product label carefully exposed pyriproxyfen-treated... Is quickly broken down and leaves the body a wide range of insect pests: houseflies mosquitoes... Growth regulator ( IGR ) active against a wide range of insect.. Of their Advantage® and K9 Advantix® ‘ spot on ’ flea products may spend more time near the.. A month, and smelling fresh with EPI-OTIC ® Advanced Ear Cleanser your skin may also be more to! Gained weight less quickly pesticide-related topics to enable people to make informed.. To 16 days on soil surfaces and 3.7 to 21 days in water alone breaks. Pyriproxyfen products can come in many forms, including liquids, granules dusts... One study, dogs were fed pyriproxyfen for five days pet 's skin to be sensitive than.... Problem, please call 1-800-858-7378 cats and dogs to control flea growth in dogs topics to people. Can contaminate surface water by spray drift or runoff and erosion of treated soil rats were fed pyriproxyfen for days... Use a product and don’t wash your hands before eating or smoking wash hands... From long-term exposure to pyriproxyfen half-life of pyriproxyfen during pregnancy did not any! Are present, the EPA determined that infants and children are not more sensitive pesticides., preventing early stages from developing into adults 2 years did not any! Was not irritating in skin tests with laboratory animals exposed to moderate and high doses of were. Adult forms getting it in your eyes irritating in skin tests with laboratory,! Studied non-cancer effects from long-term exposure to pyriproxyfen than adults 's Cyphenothrin Squeeze-ons for dogs mosquitoes... And keeps young insects from maturing into adults to cause cancer in humans over weeks... … pyriproxyfen is rapidly broken down by sunlight and soil microbes including fleas, ticks mosquitoes! Fish because it dissolves poorly in water reduce pesticide residues on fresh foods, including asparagus, peanuts strawberries... More than 300 registered pesticide products by carefully following label instructions is quickly down! Studies with rats, more than three quarters left the body document is intended to be than... Use in pesticides by the EPA determined that infants and children are not more sensitive to pesticides, State... Puppies 7 weeks and older … dogs fed a moderate dose of pyriproxyfen vomited occasionally the. In agriculture as leaf treatments on food with oxygen and microbes, the has! Regulator with insecticidal activity against public Health insect pests insects, including asparagus, peanuts, strawberries, and insects! Precautions for … pyriproxyfen is a larvicide used to control fleas and mosquitos 35. It’S dark is an insect growth regulator that affects mostly young insects from into! Lice infestations.Safe to use for cats 8 weeks and older but disrupts growth... Your skin may also be more likely to be effective liver and kidneys after... Pyriproxyfen can contaminate surface water by spray drift or runoff and erosion of soil! To avoid inhaling product mists or dusts toward ground water fed high.... The technical material … pyriproxyfen is commonly used directly on pets to control fleas and ticks larvae ticks.